Evidence-based somatic treatment of depression in adults

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Abstract

This article reviews recent studies and controversies about the effectiveness of antidepressant medications for depression. It is divided into three broad topics: (1) the heated controversy regarding how one should interpret 'efficacy studies' of antidepressants, that is, the standard placebo-controlled double-blind studies used by drug companies to gain Food and Drug Administration approval; (2) 'effectiveness studies,' open-label studies enrolling types of patients who are excluded from efficacy studies, focusing on one enormous study in particular—the STAR-D trial; and (3) the evidence base that can guide clinicians in the choice of antidepressants for particular patients. (PsycINFO Database Record (c) 2017 APA, all rights reserved)

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