How do we determine whether antidepressants are useful or not?

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Abstract

Comments on an article by F. Hieronymus et al. (see record [rid]2019-40914-001[/rid]). The authors showed that SSRIs significantly improve scores in a subset of items in the 17-item Hamilton Depression Rating Scale (HDRS-17), over and above placebo, after a treatment period of 6 weeks, irrespective of baseline depression severity. However, we think that some uncertainties exist that should temper the authors’ conclusion that the 'claim that antidepressants are useless for patients with non-severe depression has been premature and is misleading'. (PsycINFO Database Record (c) 2020 APA, all rights reserved)

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